Oral Triiodothyronine for Children Undergoing Cardiopulmonary Bypass in Indonesia
Tahapan Penelitian : Recruit
National Cardiovascular Center Harapan Kita Hospital Indonesia
Tanggal Input Registry : 29-03-2015
|Tanggal Antisipasi Studi
|Intubation time All patients after undergoing congenital heart surgery will be supported by mechanical ventilation. Duration of this support on mechanical ventilation after surgery will be assessed in the treatment group and placebo group. Thyroid supplementation will increase the cardiac function and will make the patients extubated early than the patients without supplementation.
|Inotropic score and vasoactive-inotropic score The amount of inotropic drugs are calculated and reviewed serially since cross clamp removal until all drugs are stopped.
|Judul Penelitian Popular
|Oral Triiodothyronine for Children Undergoing Cardiopulmonary Bypass in Indonesia
|Judul Penelitian Ilmiah
|Tetronine (Sodium Liothyronine) for Children Undergoing Cardiopulmonary Bypass in Indonesia
|Experimental: Tetronine Oral T3 (Tetronine) is given 1 mcg/kg every 6 hourly through naso-gastric tube since induction of anesthesia for 60 hours Intervention: Drug: Tetronine Placebo Comparator: Placebo Placebo (saccharin lactic) is given every 6 hourly through naso-gastric tube since induction of anesthesia for 60 hours Intervention: Drug: Placebo
|Jumlah Subyek Penelitian
Inclusion Criteria:- Children undergoing cardiopulmonary bypass - Age 3 years old or less - Aristotle score 6 and above - Total correction or biventricular repair
Exclusion Criteria:- Single ventricle defects - Body weight less than 2 kg at the time of recruitment - Presentation with sepsis - Tachyarrhythmia or any other arrhythmia before surgery - Creatinine level of more than 2 mg/dL - Known thyroid disease - Known lung abnormalities (incl. infection) before surgery.
|Nomor Persetujuan Etik
|Nomor Persetujuan Material Transfer Agreement
|Nomor Persetujuan Pelaksanaan Uji Klinik
|Other Study ID Numbers
|Eva M Marwali,MD, National Cardiovascular Center Harapan Kita Hospital Indonesia