Oral Triiodothyronine for Children Undergoing Cardiopulmonary Bypass in Indonesia

Tahapan Penelitian : Rekrut
Sponsor:
Mitra Pelaksana:
CRDF
No Registry
INA-Z758Y83
Tanggal Input Registry : 29-03-2015

01-06-2014
Intubation time All patients after undergoing congenital heart surgery will be supported by mechanical ventilation. Duration of this support on mechanical ventilation after surgery will be assessed in the treatment group and placebo group. Thyroid supplementation will increase the cardiac function and will make the patients extubated early than the patients without supplementation.
Inotropic score and vasoactive-inotropic score The amount of inotropic drugs are calculated and reviewed serially since cross clamp removal until all drugs are stopped.
 
Oral Triiodothyronine for Children Undergoing Cardiopulmonary Bypass in Indonesia
Tetronine (Sodium Liothyronine) for Children Undergoing Cardiopulmonary Bypass in Indonesia
Eksperimental
Experimental: Tetronine Oral T3 (Tetronine) is given 1 mcg/kg every 6 hourly through naso-gastric tube since induction of anesthesia for 60 hours Intervention: Drug: Tetronine Placebo Comparator: Placebo Placebo (saccharin lactic) is given every 6 hourly through naso-gastric tube since induction of anesthesia for 60 hours Intervention: Drug: Placebo
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Inclusion Criteria:

- Children undergoing cardiopulmonary bypass - Age 3 years old or less - Aristotle score 6 and above - Total correction or biventricular repair

Exclusion Criteria:

- Single ventricle defects - Body weight less than 2 kg at the time of recruitment - Presentation with sepsis - Tachyarrhythmia or any other arrhythmia before surgery - Creatinine level of more than 2 mg/dL - Known thyroid disease - Known lung abnormalities (incl. infection) before surgery.
 
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Eva M Marwali,MD, National Cardiovascular Center Harapan Kita Hospital Indonesia